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Kuru Disease

In this in-depth examination of Kuru disease, you will be guided to understand its complex nature, historical roots and the science that underpins it. Uncover the causes of Kuru disease, how prions have a role in its manifestation, and the crucial importance of cultural practices in its transmission. Delve into the intricate details by exploring Kuru disease at a cellular level, its physical and psychological symptoms, and learn about the contemporary treatments available. Discover the reality of curing Kuru disease and how its distinct stages impact treatment options. Empower yourself with comprehensive knowledge on this rare but significant neurological condition, Kuru disease.

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Kuru Disease

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In this in-depth examination of Kuru disease, you will be guided to understand its complex nature, historical roots and the science that underpins it. Uncover the causes of Kuru disease, how prions have a role in its manifestation, and the crucial importance of cultural practices in its transmission. Delve into the intricate details by exploring Kuru disease at a cellular level, its physical and psychological symptoms, and learn about the contemporary treatments available. Discover the reality of curing Kuru disease and how its distinct stages impact treatment options. Empower yourself with comprehensive knowledge on this rare but significant neurological condition, Kuru disease.

Understanding Kuru Disease

The field of microbiology broadens the horizons of scientific discovery and understanding. One such discovery, the Kuru Disease, intrigues researchers and students alike. Let's venture into the world of this fascinating disease.

What is Kuru Disease?

Kuru disease is a rare, degenerative, invariably fatal brain disorder. You might know it as a type of "prion disease", caused by an infectious agent known as a prion.

A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally.

Prion diseases can affect both humans and animals and are, unfortunately, commonly associated with long incubation periods. These are general features of this unique group of diseases, which also includes Creutzfeldt-Jakob disease (CJD).

  • Known as prion diseases
  • Caused by infectious agents called prions
  • Affects both humans and animals
  • Associated with long incubation periods

Kuru disease gained scientific interest due to its occurrence among the Fore people of Papua New Guinea in the early to the mid-20th century. Female tribe members and children were most often affected as they consumed the brains of deceased tribe members in acts of cannibalism. This ritualistic ingestion of prions resulted in the transmission of Kuru.

Historical Overview of Kuru Disease

The Kuru disease was first studied in the 1950s and 1960s when an epidemic broke out among the Fore people of Papua New Guinea, who named the disease after their word for "shaking" or "trembling". The peculiar occurrence and transmission habits of this disease made it a subject of extensive scientific research.

Time period Event
1950s-1960s First observation among Fore people
1997 Stanley Prusiner awarded Nobel Prize for work involving prions

In 1997, Stanley Prusiner, an American neurologist and biochemist, was awarded the Nobel Prize in Physiology or Medicine for his groundbreaking work researching prions and Kuru disease specifically.

The decline of Kuru disease after the 1960s is a prime example of a successful public health intervention. The cannibalistic rituals, which were causing the spread of the disease, were discouraged and eventually halted, leading to the drastic fall in Kuru cases. This is considered a classic case of overcoming a health crisis through understanding and influencing human behaviour.

Kuru Brain Disease: The Science Behind it

In terms of how the Kuru disease affects the brain, it causes characteristic sponge-like changes, known as spongiform changes. It also results in amyloid plaques scattered throughout the brain.

Amyloid plaques refer to extracellular deposits of insoluble proteins in the brain. They are generally associated with degenerative diseases, like Alzheimer's.

These changes are the result of a propagation of prions in the brain, which bind to normal cellular prions in the neurons and convert them into the disease-causing form. This all happens through a process called Prion Propagation, abbreviated as: \[ PP = PrP^C \rightarrow PrP^Sc \]

 
// The process of prion propagation
function prionPropagation(){
  var normalPrion = getNormalPrion();
  var diseasePrion = convertToDiseasePrion(normalPrion);
  return diseasePrion;
}

So as you can see, Kuru disease is a complex neurological condition that influences the brain's structure and function adversely.

Causes of Kuru Disease

Understanding the causative factors of Kuru disease can shed light on how it is both contracted and spread amongst individuals. Two primary elements play a pivotal role: the biological agent itself known as the prion, and the cultural practices of individuals who were most affected by this disease historically. Let's delve into these aspects with a closer look.

Transmission: The Main Cause of Kuru Disease

Regarding the main cause of Kuru disease, it's crucial to know that Kuru is one of several transmissible spongiform encephalopathies (TSEs), which are caused by prions. These prions are central to how the disease spreads, or transmits, between people.

Unlike most infections or diseases, prions themselves are not organisms that reproduce. They're misfolded proteins, capable of making other proteins misfold in a domino-like effect. Such errors in proteins cause the characteristic symptoms of prion diseases.

Studying Kuru has revealed that it is not transmitted through the air or casual contact. Instead, the transmission of Kuru, historically, was specifically associated with cannibalistic practices amongst the Fore people of Papua New Guinea. They consumed the brains and other nervous tissues of their deceased during mortuary feasts, not out of hunger, but as a means of expressing respect for the dead.

Transmissible Spongiform Encephalopathies (TSEs) are a group of progressive conditions that affect the brain (encephalopathies) and are characterized by the accumulation of an abnormal isoform of the prion protein in affected tissues.

Transmission Route Relevance to Kuru Disease
Exposure to brain or nervous tissue Main route of transmission among Fore people in Papua New Guinea
Ingestion Can lead to transmission if contaminated tissue is consumed

Hence, the route of transmission plays an essential role in understanding the prevalence and control of Kuru disease.

Kuru Disease Cause: The Importance of Cultural Practices

The emergence, spread, and eventual decline of Kuru disease cannot be disassociated from the cultural practices of the Fore people. Uncovering this connection was instrumental in curbing the disease.

The rituals followed by the Fore people involved preparing and consuming the bodies of the deceased as a sign of respect. This practice unintentionally led to the transmission of the prion protein to living individuals who then fell ill with Kuru.

The Fore didn't cook the bodies in a way that would destroy prions. As a result, ingesting the brain and nervous tissue, which are rich in prions, continually exposed the population to the Kuru disease.

When these practices were identified and curtailed in the late 20th century, a significant reduction in Kuru disease incidence was observed, providing a critical lesson on the intersection of cultural practices and disease transmission.

The Role of Prions in Kuru Disease

Understanding prions, the rogue proteins, is critical when studying the cause and spread of Kuru disease. These pathogenic agents differ significantly from bacteria, viruses, and other infectious entities traditionally studied in microbiology.

Prions are proteinaceous infectious particles, which, unlike traditional pathogens, lack nucleic acids (DNA or RNA). This fundamental distinction sets prion diseases in their own unique category.

These abnormally folded proteins, once in the body, can interact with normal brain proteins (PrPC) and cause them to misfold (into PrPSc) as well. This aggregation of misfolded proteins in the brain induces the spongiform changes that are characteristic of a prion disease like Kuru.

The molecular process, represented with the formula \[ PrP^C \rightarrow PrP^Sc \] depicts the dangerous conversion of a normal prion protein (PrPC) to a disease-causing form (PrPSc).

Hence, prions are the primary drivers behind Kuru disease and other similar conditions.

Prion Properties Impact on Disease
Resilient and hard to destroy Make prion diseases difficult to treat and prevent
Can cause normal proteins to misfold via a domino-like effect Results in aggregation of misfolded proteins and neuron damage

Importantly, the behaviour of prions and their role in Kuru disease highlights the diverse nature of pathogens and the various mechanisms through which diseases can arise and spread.

Kuru Disease Explained

Let's delve even deeper into the world of Kuru disease, one of the strangest and most fascinating phenomena in medical history. This paradigm-shifting disease challenges many traditional perspectives of microbiology and teaches us valuable lessons about the nature and diversity of infectious diseases.

The Impact of Kuru Disease on Our Bodies

Kuru disease is classified as a neurodegenerative disorder, meaning it primarily affects the neurons within the brain. Over time, infected individuals experience a deterioration of neurological functions leading to pronounced physical and mental effects. The initiation of these effects often starts with an incubation period which can span from a few years up to several decades. After this period, the disease typically progresses in three discrete phases: the ambulant, sedentary, and terminal stages.

In the ambulant stage, the first noticeable signs of Kuru include destabilisation in motor functions:

  • Tremors
  • Impaired balance
  • Coordination issues

During the sedentary stage, greater motor impairment is seen:

  • Inability to stand or walk without support
  • Severe tremors
  • Skeletal muscle jerking

Finally, in its terminal stage, Kuru can lead to:

  • Inability to sit without support
  • Loss of speech and response to surroundings
  • Difficulty swallowing

What's tragic about Kuru is that currently, there are no treatments that can halt its progress or cure it. Invariably it leads to death, usually due to pneumonia or other infections.

Exploring the Kuru Brain Disease at Cellular Level

The fundamental culprit of Kuru, as previously discussed, is the prion - a misfolded protein that can induce other proteins to misfold in a chain reaction. These prion proteins are denoted PrPSc, differentiated from their normal counterparts, PrPC. The interaction between these two versions of the prion protein is central to the pathogenesis of Kuru disease.

At the cellular level, prions essentially hijack the protein folding machinery of the cell, causing a dangerous accumulation of PrPSc protein. The PrPC proteins normally present in neurons are converted into the disease-causing PrPSc prions, through a process denoted: \[ PrP^C \rightarrow PrP^Sc \]

 
function convertPrion(normalPrion) {
  var diseasePrion = normalPrion.misfold();
  return diseasePrion;
}

This aggregation of PrPSc initiates a series of damaging effects, such as causing holes in brain tissue, resulting in a 'sponge-like' appearance. This 'spongiform' degeneration is what gives the group of disorders its name: transmissible spongiform encephalopathies.

Cellular Changes Results
Conversion of PrPC to PrPSc Cumulative prion aggregation causing cellular damage
Spongiform Changes 'Holes' in brain tissue, leading to degeneration of neuronal structure and function

Hence, the devastating power of prions lies in their ability to disrupt normal cellular processes through a domino-like effect, wreaking havoc on an individual's neurological functions.

The Link between Kuru Disease and Biological Molecules

By now, it should be clear that the pivotal molecule, or indeed, class of molecules in Kuru Disease are proteins: a host of beautiful, complex molecules which, in their vast diversity and roles, comprise the building blocks of life itself. Yet, in the form of prions, these same entities can also herald immense destruction.

Prions are a unique type of protein characterised by their abnormal conformation and ability to influence the folding of other proteins. They exemplify the undeniable influence of protein folding - and its mishaps - on normal and disease states.

The normal prion protein, denoted as PrPC, predominantly resides in the cells of our nervous system, where they are believed to play a role in the development and function of nerve cells. The structure of this protein, under normal conditions, is complex yet stable, held by a variety of molecular forces:

  • Hydrogen bonds
  • Van der Waals forces
  • Hydrophobic interactions
  • Disulfide bridges

However, when PrPC is converted into its harmful counterpart - PrPSc, the secondary and tertiary structures of the protein are significantly altered. A normally alpha-helix rich protein turns into one dominated by beta sheets. What's important to note is the high stability of this misfolded, beta-sheet-rich form, making it resistant to natural degradation processes of the body and leading to its gradual accumulation.

Ultimately, it's a story of transformation at the molecular level: an innocent protein morphs into a lethal disease-causing agent and triggers a fatal cascade of events. The workings of Kuru disease underpin how changes at the molecular level, as tiny as protein misfolding, can vastly affect an organism's survival and function.

Recognising Symptoms of Kuru Disease

Being alert to the signs and symptoms of Kuru disease is a top priority for healthcare professionals, particularly in areas where the disease was previously endemic. Recognising potential cases quickly can aid in better patient management and support, as well as contribute to our medical understanding of this rare condition.

Physical Symptoms of Kuru Disease

Kuru disease triggers an array of physical and neurological symptoms in the human body that progressively worsen over time. The symptoms can be organised into distinct stages, each carrying its own set of characteristic signs.

The ambulant stage of Kuru disease is marked by:

  • Unsteady gait or difficulty walking
  • Tremors and shaking
  • Impaired motor coordination
  • Poor muscle control and reflexes

As the disease progresses to the sedentary stage, the following signs may become evident:

  • Severe difficulty walking, eventually leading to an inability to stand without support
  • Continued and worsening tremors
  • Loss of muscle coordination leading to uncontrollable, random muscle movements and jerking

The final terminal stage of Kuru is accompanied by:

  • Complete loss of ambulatory abilities
  • Deterioration of mental faculties and responsiveness
  • Inability to swallow, leading to malnutrition and dehydration
  • Increased susceptibility to infections, often leading to death

Impact of Kuru Brain Disease on Psychological Health

While the physical symptoms of Kuru disease are severe, taking a toll on the individuals' physical health, the psychological impact of the disease cannot be underestimated. In addition to the cognitive decline initiated by the neurodegenerative effects of the disease, patients often experience a multitude of psychological symptoms. Amongst these, the most commonly observed are mood changes, anxiety, and depression.

Some patients can manifest with behaviour changes, like becoming progressively unresponsive to their surroundings or expressing bouts of uncontrollable laughter - a neuropathological symptom often termed as ‘pathological laughter’.

Moreover, the inability to carry out day-to-day functions or even the basic tasks of mobility can lead to feelings of helplessness and despair. This, combined with a progressive loss of memory and cognitive abilities, can culminate in a severe psychological burden for the patients suffering from Kuru disease.

Kuru Disease Symptoms: A Detailed Guide

A more detailed understanding of the Kuru symptoms, particularly their progression and interaction is essential for both healthcare providers and caregivers. The following table breaks down the symptoms associated with each stage of disease:

Stage Symptoms
Ambulant Stage Unsteady gait, tremors, poor coordination, reduced muscle control
Sedentary Stage Difficulty standing or walking, severe tremors, loss of muscle coordination and random muscle movements
Terminal Stage Inability to stand or walk, reduced response to surroundings, inability to swallow, increased susceptibility to infections

Nonetheless, it is important to note that these symptoms may vary from patient to patient, and the rate of progression might also differ markedly amongst individuals. Hence, it is crucial that each individual's symptoms and progression are closely monitored, with the provision of appropriate support to help manage these symptoms.

Treating and Managing Kuru Disease

As we venture deeper into the realm of Kuru disease, the discussion naturally progresses to its management and prospective treatment avenues. Despite the lack of a definitive cure, understanding how best to manage the condition can significantly improve patients' quality of life and potentially pave the way to future breakthroughs in treatment.

Exploring Treatments for Kuru Disease

Given the unique nature of Kuru disease and prion diseases as a whole, specific treatments targeting the underlying cause remain elusive. Current treatment strategies are primarily palliative, focusing on managing the individual symptoms and enhancing patient comfort. Nevertheless, significant strides have been made in research to eliminate prions.

Presently, for the physical symptoms, symptomatic relief is aimed at making the patients comfortable during their different stages of the disease. Measures like physiotherapy and assistive mobility devices may aid in dealing with balance and coordination issues in the early stages. For the later stages, a significant part of the care is supportive, tending to the patient's comfort and managing secondary issues like malnutrition, hydration, and prevention of infections as swallowing becomes compromised.

For psychological symptoms, counselling and support to the patients and their family may aid considerably, especially in dealing with the emotional stress and burden associated with the disease.

Prion-targeted treatments are still in the research phase, and a few experimental approaches are being examined. These include:

  • Immunotherapy: This approach utilises specific antibodies that can bind to PrPSc, marking them for destruction.
  • Drug treatments: Certain drugs, such as quinacrine and amphotericin B, have demonstrated some ability to interfere with prion replication. However, their widespread use is limited by severe side-effects and not-so-effective results across different prion diseases.
  • Gene silencing: RNA interference technologies aim to decrease the overall production of prion proteins in the body, thereby reducing the number of proteins that can potentially misfold and form prions.

The Reality of Kuru Disease Cure: Is It Possible?

The complex nature of prion diseases, including Kuru, presents a significant challenge for researchers. The unconventional nature of the infectious agents and the irreversible damage to the brain they cause render traditional therapies ineffective.

As it stands, a complete cure for Kuru disease remains out of reach. Owing to its slow-progressing nature, by the time clinical symptoms appear, significant brain damage has usually occurred, and this is currently irreversible. The fact that the folded PrPSc prions are highly resistant to all known sterilisation procedures only compounds the issue.

However, this is not to say that a cure is unattainable in the future. Scientific advancements continue to shed light on prion diseases and how they operate at a molecular level. The quest for a cure for Kuru disease and other prion diseases is very much ongoing, with numerous experimental approaches and therapeutic targets under intensive investigation. These range from preventing prion proteins' conversion to their lethal forms to boosting the body's own defences against prions.

Kuru Disease Stages and Their Impact on Treatment Options

The progression of Kuru disease through various stages impacts not only the symptoms experienced by the patient, but also the suitability and effectiveness of various treatment options. Understanding the stage-based progression of the disease can aid healthcare professionals in devising a more targeted and efficient treatment plan for Kuru patients.

During the ambulant stage, when the symptoms are milder and primarily involve motor coordination issues, physiotherapy and occupational therapy can help improve mobility and strength. Such interventions may extend the patient's ability to perform daily activities and maintain independence for as long as possible.

In the sedentary stage, as the symptoms become more severe, treatment shifts towards managing these symptoms and improving quality of life. Medications can be used to manage tremors and muscle jerkiness. Assistive devices can aid in mobility, and speech therapy may benefit those experiencing difficulty with swallowing. High-nutrition food and fluids can also help combat weight loss and dehydration.

By the terminal stage, the focus lies predominantly on palliative care. The primary objective is to make the patient as comfortable as possible and manage any secondary infections or complications.

It is important to remember, however, that due to the variability in Kuru's progression, each patient will have a unique experience with the disease. Therefore, patient monitoring and symptom management should be personalised and flexible to ensure the best possible outcome.

Ultimately, even though the journey to a definitive cure for Kuru remains a marathon yet to be completed, ample hope remains in the form of ongoing research and developing understanding of the disease. As we continue to accumulate knowledge about prions and their interesting yet devastating potentialities, we can remain hopeful that the possibilities for prevention, treatment, or even a cure for Kuru disease are not far off.

Kuru Disease - Key takeaways

  • Prions are misfolded proteins, not organisms, that cause other proteins to misfold resulting in prion diseases.
  • Kuru disease is historically associated with cannibalistic practices among the Fore people of Papua New Guinea, where consumption of the brains and other nervous tissues of their deceased led to the transmission of prions.
  • Kuru disease involves the progressive accumulation of an abnormal isoform of the prion protein, leading to a group of conditions known as Transmissible Spongiform Encephalopathies (TSEs).
  • The disease progresses in three stages: the ambulant stage (characterized by tremors, impaired balance and coordination issues), the sedentary stage (which involves inability to stand or walk without support, severe tremors and skeletal muscle jerking), and the terminal stage (where the individual loses speech, response to surroundings, and ability to swallow).
  • At the cellular level, prions hijack the protein folding machinery of cells, causing an accumulation of disease-causing prions, resulting in bodily damages such as 'holes' in brain tissue, which give these disorders their name: transmissible spongiform encephalopathies.

Frequently Asked Questions about Kuru Disease

Kuru disease is a rare, fatal neurodegenerative disorder, occurring predominantly among the Fore people in Papua New Guinea. It's caused by prions and primarily characterised by tremors, lack of coordination and neurological degeneration. It's notably transmitted through participation in cannibalistic rituals.

Kuru disease is caused by an infectious agent known as a prion. It's transmitted through a ritualistic practice of cannibalism, particularly consuming the brains of the deceased, which was common among the Fore people of Papua New Guinea.

Kuru disease symptoms include tremors, unsteady movement, lack of coordination, mood swings, difficulty walking, and severe uncontrolled laughter. As the disease progresses, the individual may have difficulty swallowing, experience malnutrition, and eventually become unable to move or talk.

No, Creutzfeldt-Jakob Disease (CJD) and Kuru are not the same but both belong to a group of neurodegenerative disorders known as prion diseases. Kuru was predominantly found in Papua New Guinea and linked to cannibalism, while CJD is more globally distributed with varied causes.

The stages of Kuru disease are: the Ambulatory stage with unsteady stance and gait; the Sedentary stage where the patient cannot walk unaided; the Terminal stage which leads to the inability to sit without support, severe intellectual impairment, and death, typically due to pneumonia.

Final Kuru Disease Quiz

Kuru Disease Quiz - Teste dein Wissen

Question

What is Kuru disease and what causes it?

Show answer

Answer

Kuru disease is a rare, invariably fatal brain disorder known as a type of prion disease. It is caused by an infectious agent known as a prion, which can trigger normal proteins in the brain to fold abnormally.

Show question

Question

How was Kuru disease historically transmitted among the Fore people?

Show answer

Answer

The Kuru disease was historically transmitted among the Fore people of Papua New Guinea through cannibalism, particularly when female tribe members and children consumed the brains of the deceased which contained prions.

Show question

Question

What are the characteristics changes Kuru disease causes in the brain?

Show answer

Answer

Kuru disease causes characteristic sponge-like changes in the brain, known as spongiform changes, and results in amyloid plaques scattered throughout the brain. These changes result from the propagation of prions in the brain.

Show question

Question

What is the primary cause of Kuru disease?

Show answer

Answer

Kuru disease is primarily caused by prions, misfolded proteins that make other proteins misfold, and is historically associated with cannibalistic cultural practices of the Fore people in Papua New Guinea.

Show question

Question

How does the transmission of prions occur in Kuru disease?

Show answer

Answer

Prions are transmitted through the ingestion of brain or nervous tissue, specifically through the cannibalistic practices of the Fore people who consumed the brains and nervous tissue of their deceased during mortuary feasts.

Show question

Question

What caused the decline of Kuru disease among the Fore people?

Show answer

Answer

The decline of Kuru disease among the Fore people came about when their traditional practices of consuming the bodies of the deceased were identified and curtailed in the late 20th century.

Show question

Question

What is Kuru disease and how does it progress?

Show answer

Answer

Kuru disease is a neurodegenerative disorder that affects neurons in the brain. It includes an incubation period which can last several years to decades. The disease progresses in three stages: the ambulant stage with tremors and balance issues, the sedentary stage featuring motor impairment, and the terminal stage leading to loss of speech, response, and difficulty swallowing. It is currently incurable.

Show question

Question

What is a prion and why is it crucial in Kuru disease?

Show answer

Answer

A prion is a type of protein characterised by its abnormal conformation and ability to influence the folding of other proteins. In Kuru disease, the normal prion proteins in neurons are converted into disease-causing prions. This results in a dangerous accumulation of misfolded prions, leading to cellular damage and neural degeneration.

Show question

Question

What is the transformation that occurs at the molecular level in Kuru disease?

Show answer

Answer

In Kuru disease, the normal prion protein (PrPC) is converted into its harmful counterpart, PrPSc. The secondary and tertiary structures of the protein change significantly in this transformation, turning an alpha-helix-rich protein into a beta-sheet-rich protein. This misfolded form is highly stable, resistant to the body's natural degradation processes, and accumulates over time.

Show question

Question

What are the physical symptoms during the ambulant stage of Kuru disease?

Show answer

Answer

Unsteady gait or difficulty walking, tremors and shaking, impaired motor coordination and poor muscle control and reflexes.

Show question

Question

What psychological symptoms can occur in patients with Kuru disease?

Show answer

Answer

Mood changes, anxiety, depression, behaviour changes including becoming unresponsive or bouts of uncontrollable laughter, feelings of helplessness and despair.

Show question

Question

What are the symptoms during the terminal stage of Kuru disease?

Show answer

Answer

Complete loss of ambulatory abilities, deterioration of mental faculties and responsiveness, inability to swallow, and increased susceptibility to infections.

Show question

Question

What is the primary focus of current treatment strategies for Kuru disease?

Show answer

Answer

Current treatment strategies primarily aim at managing the individual symptoms and enhancing patient comfort, as a definitive cure doesn't exist. They also deal with secondary issues like malnutrition and hydration, and prevention of infections.

Show question

Question

What are some experimental treatment approaches being investigated for Kuru and other prion diseases?

Show answer

Answer

Experimental treatment approaches include immunotherapy, which utilises specific antibodies that bind to PrPSc- marking them for destruction, certain drugs interrupting prion replication, and gene silencing technologies reducing the overall production of prion proteins.

Show question

Question

How does the progression of Kuru disease impact the course of treatment?

Show answer

Answer

The progression of Kuru disease affects the treatment options. In the ambulant stage, therapies aim to improve mobility. In the sedentary stage, treatments focus on symptom management, and in the terminal stage, the emphasis is on palliative care to maximise patient comfort.

Show question

Test your knowledge with multiple choice flashcards

What is Kuru disease and what causes it?

How was Kuru disease historically transmitted among the Fore people?

What are the characteristics changes Kuru disease causes in the brain?

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Flashcards in Kuru Disease15

Start learning

What is Kuru disease and what causes it?

Kuru disease is a rare, invariably fatal brain disorder known as a type of prion disease. It is caused by an infectious agent known as a prion, which can trigger normal proteins in the brain to fold abnormally.

How was Kuru disease historically transmitted among the Fore people?

The Kuru disease was historically transmitted among the Fore people of Papua New Guinea through cannibalism, particularly when female tribe members and children consumed the brains of the deceased which contained prions.

What are the characteristics changes Kuru disease causes in the brain?

Kuru disease causes characteristic sponge-like changes in the brain, known as spongiform changes, and results in amyloid plaques scattered throughout the brain. These changes result from the propagation of prions in the brain.

What is the primary cause of Kuru disease?

Kuru disease is primarily caused by prions, misfolded proteins that make other proteins misfold, and is historically associated with cannibalistic cultural practices of the Fore people in Papua New Guinea.

How does the transmission of prions occur in Kuru disease?

Prions are transmitted through the ingestion of brain or nervous tissue, specifically through the cannibalistic practices of the Fore people who consumed the brains and nervous tissue of their deceased during mortuary feasts.

What caused the decline of Kuru disease among the Fore people?

The decline of Kuru disease among the Fore people came about when their traditional practices of consuming the bodies of the deceased were identified and curtailed in the late 20th century.

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