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Biology

If someone were to ask you what biology was, how would you reply? Biology is quite a complex concept to explain. Does it study plants, animals and humans only, or does it cover much more than that? 

StudySmarter’s Biology Revision and Notes will show you that biology is the study of life. In fact, it is the study of ALL life and even some things that are classified as not living – viruses, for instance. Biological study starts from the smallest atoms and molecules, such as carbon atoms in the proteins that digest our food. Biology then examines larger structures, such as tissue, organs, and whole organisms, including bacteria, viruses, plants, animals, and humans. It continues with the study of topics including genetic diversity, the evolution of species, and ecosystems. 

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If someone were to ask you what biology was, how would you reply? Biology is quite a complex concept to explain. Does it study plants, animals and humans only, or does it cover much more than that? StudySmarter’s Biology Revision and Notes will show you that biology is the study of life. In fact, it is the study of ALL life and even some things that are classified as not living – viruses, for instance. Biological study starts from the smallest atoms and molecules, such as carbon atoms in the proteins that digest our food. Biology then examines larger structures, such as tissue, organs, and whole organisms, including bacteria, viruses, plants, animals, and humans. It continues with the study of topics including genetic diversity, the evolution of species, and ecosystems.

Our planet Earth is one massive, incredible ecosystem! It is packed with various forms of life, from the smallest microorganisms to plants and large animals. These forms of life interact with one another; they move, reproduce, and live in oceans, grass, cities, villages, etc. Imagine you are standing on the top of a mountain, looking down at all this diversity. That is all included in the study of life, i.e. biology. Impressive, isn’t it?

Biology topics and learning objectives

On StudySmarter, you will find vital resources for your biology courses. We follow specifications developed by expert teachers of biology. This way, we ensure our content is high-quality and relevant to all who embark on a learning journey with StudySmarter. Most biology courses cover the following topics:

  • Biological molecules.

  • Cells.

  • Substance exchange.

  • Genetic information.

You’ll find those on StudySmarter, but we also offer you these topics as well:

  • Energy transfers.

  • Responding to change.

  • Genetics, populations, evolution and ecosystems.

  • Control of gene expressions.

Let’s introduce all the biology topics.

Biology: Biological molecules

Biological molecules are carbon-based compounds essential for most biological processes.

Biological molecules serve as the structural components of molecules and cells, such as simple carbohydrates in bases of DNA and RNA and complex carbohydrate cellulose in plant walls. Moreover, biological molecules called lipids build cell membranes, forming a phospholipid bilayer. Some biological molecules, like proteins, act as enzymes, messengers and hormones, carrying out metabolic functions. Nucleic acids, DNA and RNA, carry the genetic information in all living things and viruses. The other two essential biomolecules are ATP (adenosine triphosphate) and water, necessary for cellular processes.

Biology Revision and Notes Biological Molecules diagram StudySmarterDiagram of a molecule. Source: Canva

Biology: Cells

Cells are the smallest units of life. The study of cells is one of the most significant in biology.Cells can be either prokaryotic or eukaryotic. They contain genetic material and divide to create new cells. Eukaryotic cells divide with processes called mitosis and meiosis. Prokaryotic cells divide by binary fission.

Cells vary in the number and type of organelles, which are subunits inside all cells. One of the essential structural components of the cell is the cell surface or plasma membrane. It serves as a protective layer and is the main player in transporting vital substances in and out of cells. Specialised cells called T lymphocytes and B lymphocytes are crucial for our immune systems. These cells aid in the fight against diseases.

Biology Revision and Notes Cells StudySmarterEukaryotic cells: an animal cell and a plant cell. Source: Freepik.com by brgfx.

Biology: Substance exchange

Substance exchange in biology is the exchange of substances (e.g. glucose) between the internal and external environments of cells.

This is how organisms get oxygen and nutrients from the external environment and get rid of metabolic waste. Multicellular organisms require specialised organ systems for substance exchange because their surface area to volume ratio is too small to rely on cell membranes as an exchange surface.

Substance exchange in plants is called a mass flow system. The mass flow systems of plants comprise xylem and phloem. Substance exchange in animals happens in different organ systems, including the digestive, respiratory, and circulatory systems. Digestion and absorption of nutrients occur in the digestive system, whereas gas exchange takes place in the respiratory system. The circulatory system pumps and circulates blood that carries nutrients and oxygen. This role of the circulatory system is crucial to ensure the high metabolic activity of cells for all of the organ systems in the body to function properly.

Biology Revision and Notes Substance Exchange Human Heart StudySmarterDiagram of the human heart. Source: smart.servier.com

Biology: Genetic information

DNA is a remarkable molecule consisting of our genetic material. Genetic material is involved in every aspect of biology, making DNA an essential molecule for the continuation of life.

The DNA in the nucleus is organised into genes made of nucleotides, which are found on chromosomes. Sometimes, the order of these nucleotides goes wrong, and mutations occur. Different mutations have different effects on the organism, but one of the beneficial effects is introducing genetic diversity into a species. Genetic diversity is also achieved during meiosis (a type of cell division) which allows DNA to be switched around so that the sex cells (also called gametes) have a different combination of DNA.

As a result of this vast genetic diversity in organisms, we have millions of species that we need to organise and classify. This is the study of taxonomy. Complementary to genetic diversity is the biodiversity we see in communities. We can quantify this level of diversity using measurements such as the index of biodiversity and species richness.

Biology Revision and Notes Genetic Information DNA and RNA StudySmarterDNA and RNA. Source: smart.servier.com

Biology: Energy transfers

The term energy transfer refers to the changes in energy that occur in and between organisms within an ecosystem.

All life depends on energy, which is usually derived from the Sun. The transfer of this energy between different organisms allows them to maintain their highly ordered environments and communities.

When it comes to how energy is transferred, there are two types of organisms: autotrophs, including plants, lichens or algae, and heterotrophs, including animals and humans. Most autotrophs gain energy from the Sun via photosynthesis. This process involves autotrophs using light energy to turn carbon dioxide and water into glucose and oxygen. Heterotrophs cannot synthesise their own energy and rely on acquiring it through consuming other organisms. They perform an inverse process to photosynthesis: they take glucose and oxygen and turn them into carbon dioxide and water. This energy transfer is called respiration.

Biology Revision and Notes Energy Transfers Photosynthesis StudySmarterPlants use the energy from the Sun for photosynthesis. Source: Canva

Biology: Responding to change

Organisms respond to change in the internal and external environments. The change comes in the form of a stimulus. The stimuli (singular stimulus) can be a physical or chemical change and are recognised by specialised cells called receptors. The response to the stimuli is crucial for the survival of species. Neurones or nerve cells are cells specialised for transporting nerve impulses. There are millions of neurones in mammals, making up the complex and fascinating nervous system. Some of the organs coordinated by the nervous system are the muscles. Contraction of skeletal muscles starts with an action potential reaching and travelling deep into muscle fibres, ultimately triggering the sliding filament mechanism. All these responses to changes are necessary for the body to maintain a constant internal environment. This is called homeostasis. Living organisms require a consistent temperature, pH, and an overall chemical balance to function.

Biology Revision and Notes Responding to Change Synapse and transmission of nerve impulses StudySmarterDiagram of a synapse and the transmission of nerve impulses. Source: smart.servier.com

Biology: Genetics, populations, evolution and ecosystems

Individual members of one species have the same set of genes but can vary in combinations of alleles. Alleles are different forms of a gene responsible for the genetic diversity in species. The more alleles in the genome of a species, the greater the genetic diversity. When members of one species live together in a habitat, they form populations. These, in turn, form communities where diverse species cohabit and interact with one another. The population size can vary and is affected by biotic (living) and abiotic (non-living) factors. For instance, competition and predation within or between different species are biotic factors, while the pH and temperature in the species’ habitat are abiotic factors.

Communities and the environment they inhabit make up ecosystems. An ecosystem is a self-sustaining, dynamic system that includes all living organisms (biotic part of the ecosystem) and the physical environment (abiotic components).

Biology Revision and Notes Genetics and Ecosystem animals and plants in a habitat StudySmarterA varied ecosystem with animals, plants and their habitat. Source: Freepik.com by macrovector

Biology: Control of gene expression

Some of the DNA in our cells can contain mutations. Considering all cells start off with the same genome, how can they have different functions and features, i.e. mutations? It is because of different levels of gene expression. Some genes in the genome are switched ‘on’, meaning they are expressed, and the proteins they code for are made, while other genes are switched ‘off’, meaning the corresponding protein is not synthesised.

Mutations can affect the level of expression, but epigenetics also plays a significant role. Epigenetics investigates the modifications made to DNA and their associated proteins and how this affects the level of gene expression. Other influencing factors include processes happening before transcription and before and after translation.

These investigations into DNA and genes require remarkable gene technologies, which have been used to develop advanced medical techniques such as gene therapy and forensic technology such as genetic fingerprinting.

 Biology Revision and Notes Control of Gene Expression investigating DNA and genes StudySmarterA scientist investigating DNA and genes. Source: Canva

How can StudySmarter support me in studying Biology?

Whether you are revising the topics covered in your biology course or studying for your upcoming exams, StudySmarter has got you covered. Our original, efficient, smart, and interactive learning system allows you to master biology like never before. What’s more, it’s all free! What is the secret? How do we do it? To find out more, follow our Biology Revision Guide.

Biology Revision and Notes StudySmarter Support for Biology exams StudySmarterpch.vector at freepik.com, edited in Canva

The Biology Revision Guide

Our intelligent guide is here to introduce everything you need to know to revise your biology courses and exams successfully. Here is what you can discover on StudySmarter:

Biology summaries

StudySmarter biology summaries cover all you need to know about essential topics in biology, introducing interesting facts that will deepen your understanding and appreciation of the subject. Did you know that a human heart goes through a cardiac cycle that is only 0.8 seconds long?You can also become a creator yourself by uploading your biology coursework: summaries, workbooks, notes, and more.

Biology flashcards

Flashcards are a fantastic feature helping you learn in an easy and fun way. Biology flashcards contain questions and answers on topics covered in the summaries. Did you know that you can create your flashcards with particular questions YOU want to practice? How cool is that!

Biology study groups

You don’t have to stop at creating and uploading your material. StudySmarter lets you form study groups and learn with your friends and biology students from wider learning communities. Remember the flashcards? You can use them to quiz fellow group members and test their knowledge. This way, you can create a personalised Biology quiz! Learn, create, quiz – repeat.

Rewards for learning Biology

StudySmarter is your next best friend, encouraging you to learn and achieve top results. StudySmarter lets you set your weekly goals: complete subjects, correctly answer flashcards, ask questions. Reaching these goals will earn you trophies. For example, gain the Best thing since sliced bread if you study every week for three months, or become a Grandmaster if you answer five questions in the same course. The more you learn, the more trophies you get to celebrate your hard work.

Biology Revision and Notes Rewards for learning Biology StudySmarterStudySmarter trophies: earn while you learn!Source: Freepik.com by makyzz, edited in Canva

The Biology Team

Our StudySmarter Biology Team is made up of subject-matter experts with knowledge of and experience in teaching, learning, writing, and research related to biology and related sciences. The Biology Team is always hard at work, working diligently and enthusiastically to bring you easy-to-understand explanations of complex topics that are tailored to your courses and exams in biology.

Let's meet the Biology Team!

Biology Team Lead

Laura Sotillos

Laura holds a Masters in Neuroscience, and is an expert in the intersection of genetics and psychiatry, as well as a lover of Nature.

Biology Subject-Matter Experts

João Aguiar

João has a Master of Science in Molecular Medicine and is interested in everything related to molecular and synthetic biology.

Charlotte Berdat

With a master's degree in Biochemistry, Charlotte is an expert in ethnobotany and all things disease aetiology.

Quisha Bustamante

Quisha has a bachelor's degree in Biomedical Sciences and is an expert in infectious diseases and pathogens.

Lillian Bieszke

Lillian has her bachelor's degree in Biosystems Engineering and focuses mainly on biomedical engineering.

Isadora Santos

Isadora has a bachelor's degree in Biology (with a focus on Microbiology) and a special interest in fungi.

Daniela Lin

Daniela, who has a bachelor's degree in Microbial Biology, is a fan of data visualization, graphic design, and computational genomics.

Xavier Gagné

With a Bachelor of Science in Geology, Xavier is an expert in hydrogeology, soils, and environmental health.

Nicole Reasonda

Nicole has a Bachelor of Science in Community Development, and she focuses specifically on psychology and neuroscience.

Tiarnán McKeever

Tiarnán is currently a medical student, and he has a special interest in psychiatry.

Victoria Harper-Alexander

Victoria is currently completing her PhD in Biomedical Science (she has a Master of Science in Molecular Biology and Neuroscience) and is passionate about bioinformatics and virology.

Agastya Sharma

Agastya has a Bachelor of Science in Marine Biology with a special interest in animal biology.

Odeta Razmaite

With a master's degree in Marine Science, Odeta has an interest in the environment, conservation, and all things marine, especially marine invertebrates.

Final Biology Quiz

Biology Quiz - Teste dein Wissen

Question

Both DNA and RNA are _____ acids.

Show answer

Answer

Nucleic.

Show question

Question

Compare the functions of DNA and RNA.


Show answer

Answer

DNA stores genetic information while RNA transfers this genetic information for protein synthesis.

Show question

Question

Where is DNA found in the cells of eukaryotes and prokaryotes?


Show answer

Answer

In eukaryotes, DNA is in the nucleus, mitochondria and chloroplast (in plants). 


In prokaryotes, DNA is in the nucleoid and plasmids.

Show question

Question

Where is RNA found in the cells of eukaryotes and prokaryotes?


Show answer

Answer

In eukaryotes, RNA is in the nucleolus and ribosomes. 


In prokaryotes, RNA is in the nucleoid, plasmids and ribosomes.

Show question

Question

Identify the three different types of RNA.


Show answer

Answer

Messenger RNA (mRNA), transfer RNA (tRNA) and ribosomes RNA (rRNA).

Show question

Question

What nitrogenous bases can DNA nucleotides have?


Show answer

Answer

Adenine, thymine, cytosine or guanine.

Show question

Question

What nitrogenous bases can RNA nucleotides have?


Show answer

Answer

Adenine, uracil, cytosine and guanine.

Show question

Question

Identify the pyrimidine and purine bases. 


Show answer

Answer

The pyrimidine bases are cytosine, uracil and thymine. 


The purine bases are adenine and guanine.

Show question

Question

DNA contains the _____ pentose sugar while RNA contains the _____ pentose sugar. 


Show answer

Answer

Deoxyribose. 

Ribose.

Show question

Question

________ reactions form polynucleotides while _____ reactions break polynucleotides. 

Show answer

Answer

Condensation. 

Hydrolysis.

Show question

Question

What are phosphodiester bonds and how are they formed?


Show answer

Answer

Phosphodiester bonds link nucleotides together. They are formed between the phosphate group of one nucleotide and the hydroxyl group at the 3 'pentose sugar of another nucleotide.

Show question

Question

Compare the structure of a DNA and RNA molecule. 


Show answer

Answer

DNA is an anti-parallel double helix made of 2 polynucleotide strands while RNA is a single-stranded molecule made of 1 polynucleotide strand.

Show question

Question

What is complementary base pairing? 


Show answer

Answer

Complementary base pairing is the joining of a pyrimidine base to a purine base via hydrogen bonds.

Show question

Question

In complementary base pairing, how many hydrogen bonds are formed between the base pairs?


Show answer

Answer

Adenine forms 2 hydrogen bonds with thymine in DNA, or uracil in RNA. 


Cytosine forms three hydrogen bonds with guanine.

Show question

Question

DNA and RNA are polynucleotides. The monomers that make up these polynucleotides are called _____.

Show answer

Answer

Nucleotides.

Show question

Question

Name the process where water from plants is inevitably lost when stomata are opened for gas exchange.


Show answer

Answer

Transpiration

Show question

Question

Do plants also require oxygen? Describe the adaptations of plants in maximising the absorption of oxygen.


Show answer

Answer

Plants also require oxygen for respiration. Leaves have sufficient oxygen because it is a byproduct of photosynthesis. Other plant parts adapt to maximising the absorption of oxygen by branching and having air spaces between cells. These adaptations serve to increase the surface area of plants to facilitate the diffusion of oxygen.


Show question

Question

Translocation is the term used to describe mass flow in the phloem only. (True/ False)


Show answer

Answer

False - translocation is the term used to describe mass flow in BOTH the xylem and phloem


Show question

Question

The xylem transports water, whereas the phloem transports substances made by photosynthesis (True/ false). 


Show answer

Answer

True

Show question

Question

Briefly explain why animals have a circulatory system that consists of a pump-like organ (heart) and more complex vessels for substance exchange.


Show answer

Answer

Animals have greater metabolic demands. Thus, circulatory systems serve to maximise the efficiency of substance exchange.

Show question

Question

Fill in the blanks.

The gas exchange surfaces in fish are composed of structures called ____ that are divided into ______ that contain many ______.


Gas exchange occurs in the _____ which follow the ____________ ______. This means that ____ and _____ inside flow in ______ directions.

Show answer

Answer

The gas exchange surfaces in fish are composed of structures called gills. Gills are divided into filaments that contain many lamellae.


Gas exchange occurs in the lamellae, which follow the counter-current system. This means that the blood and water inside flow in opposite directions.

Show question

Question

Instead of capillaries, gas exchange in insects occurs in the trachea as they form direct contact with respiring cells. (True/ False)


Show answer

Answer

True

Show question

Question

Outline how the alveoli are adapted for gas exchange.

 

Show answer

Answer

The alveoli are adapted for gas exchange via their thin (i.e. one cell thick) walls and close proximity with capillaries.

Show question

Question

The heart is made up of specialised muscle cells that contract voluntarily (True/ False)

Show answer

Answer

False - the heart is made up of specialised muscle cells that contract INVOLUNTARILY


Show question

Question

Multicellular organisms have a large surface area to volume ratio (True/ False)


Show answer

Answer

False - multicellular organisms have a SMALL surface area to volume ratio

Show question

Question

Fill in the blanks.

Multicellular organisms require circulatory systems due to their _____ surface area to volume ratio. Therefore they cannot rely on _____ alone like unicellular organisms (e.g. yeasts) for the exchange of substances. This is because their large _____ require substances to travel large ______ to enter. Subsequently, the surface for substances to enter proportionately______, ultimately becoming too _________if diffusion is the only means of exchanging substances .


Animals need a _____ because of their high metabolic rate necessary for generating sufficient energy (ATP). As animals are unable to ______ like plants, they have the capacity for _______ to obtain food. A biological pump is then essential for maximal _____ of the exchange of metabolic substances across cells.

Show answer

Answer

Multicellular organisms require circulatory systems due to their small surface area to volume ratio. Therefore they cannot rely on diffusion alone like unicellular organisms (e.g. yeasts) for the exchange of substances. This is because their large sizes/volumes require substances to travel large distances to enter. Subsequently, the surface for substances to enter proportionately reduces, ultimately becoming too time-consuming if diffusion is the only means of exchanging substances.


Animals need a heart because of the high metabolic rate necessary for generating sufficient energy (ATP). As animals are unable to photosynthesise like plants, they have the capacity for locomotion to obtain food. A biological pump is then essential for maximal efficiency of the exchange of metabolic substances across cells.


Show question

Question

Double circulatory systems are found in organisms where oxygen demand is low (True/ False)

Show answer

Answer

False - single circulatory systems are found in organisms where oxygen demand is low

Show question

Question

Venules are a type of blood vessel (True/ False)


Show answer

Answer

True

Show question

Question

The circulatory system produces hormones such as insulin (True/ False)


Show answer

Answer

False - insulin is produced in the pancreas, the circulatory system TRANSPORTS insulin to target cells

Show question

Question

What kind of molecules are biological molecules?

Show answer

Answer

Biological molecules are organic molecules, meaning they contain carbon and hydrogen. 


Show question

Question

All biological molecules are organic. 

True or False.

Show answer

Answer

False. Water is an example of an inorganic biological molecule. 

Show question

Question

What are the three chemical bonds in biological molecules?


Show answer

Answer

Covalent, hydrogen, and ionic bonds.


Show question

Question

What kind of covalent bonds form when there is an uneven distribution of electrons?


Show answer

Answer

A polar covalent bond.


Show question

Question

How many covalent bonds can a carbon atom form?


Show answer

Answer

​4

Show question

Question

What are the four major biological macromolecules?


Show answer

Answer

The four major biological macromolecules are: 

  • carbohydrates
  • lipids
  • proteins 
  • nucleic acids: DNA and RNA.

Show question

Question

What are the different types of carbohydrates?


Show answer

Answer

Monosaccharides, disaccharides, and polysaccharides.


Show question

Question

What is the covalent bond between monosaccharides called?

Show answer

Answer

A glycosidic bond.

Show question

Question

What are the building blocks of lipids?

Show answer

Answer

Fatty acids and glycerol

Show question

Question

What are the two major types of lipids?

Show answer

Answer

Triglycerides and phospholipids.

Show question

Question

What is the covalent bond in lipids called?

Show answer

Answer

An ester bond.

Show question

Question

What are the four different protein structures?

Show answer

Answer

Primary, secondary, tertiary, and quaternary. 

Show question

Question

The covalent bond between amino acids is called a phosphodiester bond. True or False

Show answer

Answer

False. It is called a peptide bond. 

Show question

Question

What are monomers of nucleic acids called?

Show answer

Answer

Nucleotides. 

Show question

Question

What are the two types of nucleic acids?

Show answer

Answer

DNA and RNA

Show question

Question

What is the covalent bond between nucleotides called?

Show answer

Answer

A phosphodiester bond. 

Show question

Question

Outline the four different functions of circulatory systems.

Show answer

Answer

  • supply respiring cells with nutrients such as glucose (e.g. from small intestines to respiring tissues)
  • maintain a constant supply of oxygen to cells undergoing aerobic respiration (e.g., from lungs to respiring tissues)
  • rid metabolic waste products (e.g., carbon dioxide in respiring tissues back to the lungs)
  • transporting substances made from one part of the body to another (e.g., hormones such as insulin made in the pancreas to muscle cells)

Show question

Question

The blood pressure in the systemic circulation is higher than in the pulmonary circulation (True/ False)


Show answer

Answer

True

Show question

Question

Oxygenated and deoxygenated blood are mixed together to allow cells to receive as much oxygen as possible (True/ False)


Show answer

Answer

False - oxygenated and deoxygenated blood are separated to allow cells to receive as much oxygen as possible

Show question

Question

Fill in the blanks.

A single circulatory system has only ____ circulatory route that involves _____ sets of capillaries. The first set of capillaries facilitate the exchange of gases  _____ and ______,  whereas the second set is where the exchange of substances between the ______ and ______ occurs. Blood is said to travel _______ through the heart on one complete circuit. The single circulatory system is common in organisms where _____ ______ is ____, such as fish, echinoderms and earthworms.


On the other hand, a double circulatory system has ____circulatory routes. The ____ route carries ____ blood to the body, then _______ back to the heart after cellular gas exchange. Whereas the ______ route carries _______ blood to the lungs and back to the _____ upon oxygenation. Blood is said to travel _____ through the heart on one complete circuit. The double circulatory system is found in all _____- blooded animals and also _____.

Show answer

Answer

A single circulatory system has only one circulatory route that involves two sets of capillaries. The first set of capillaries facilitate the exchange of the gases oxygen and carbon dioxide,  whereas the second set is where the exchange of substances between the blood and cells occurs. Blood is said to travel once through the heart on one complete circuit. The single circulatory system is common in organisms where oxygen demand is low, such as fish, echinoderms and earthworms.


On the other hand, a double circulatory system has two circulatory routes. The systemic route carries oxygenated blood to the body, then deoxygenated blood back to the heart after cellular gas exchange. Whereas the pulmonary route carries deoxygenated blood to the lungs and back to the heart upon oxygenation. Blood is said to travel twice through the heart on one complete circuit. The double circulatory system is found in all warm-blooded animals and also reptiles.

Show question

Question

The circulatory system moves ammonia produced via deamination in the liver to the kidneys (True/ False)

Show answer

Answer

True


Show question

Flashcards in Biology13828

Start learning

Both DNA and RNA are _____ acids.

Nucleic.

Compare the functions of DNA and RNA.


DNA stores genetic information while RNA transfers this genetic information for protein synthesis.

Where is DNA found in the cells of eukaryotes and prokaryotes?


In eukaryotes, DNA is in the nucleus, mitochondria and chloroplast (in plants). 


In prokaryotes, DNA is in the nucleoid and plasmids.

Where is RNA found in the cells of eukaryotes and prokaryotes?


In eukaryotes, RNA is in the nucleolus and ribosomes. 


In prokaryotes, RNA is in the nucleoid, plasmids and ribosomes.

Identify the three different types of RNA.


Messenger RNA (mRNA), transfer RNA (tRNA) and ribosomes RNA (rRNA).

What nitrogenous bases can DNA nucleotides have?


Adenine, thymine, cytosine or guanine.

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